Cytotoxic T lymphocyte memory: role in cross-protective immunity against influenza?
نویسندگان
چکیده
Department of Virology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. (Received 14 October 1994; accepted 19 October 1994) the protection from subsequent inthtenza virus infections is controversial. Despite the existence of conserved CTL epitopes present in e.g. the nucleoprotein (NP)‘“*l‘ of influenza virus strains that infect humans in subsequent seasons, there is apparently little or no protective effect mediated by CTLs directed against these epitopesi2. For this reason it is argued that predominantly the presence of virus neutralizing (VN) antibodies with the relevant specificities for the hemaglutinin (HA) and the neuraminidase (NA) membrane glycoproteins of the actually circulating influenza virus strains is protective: protection against
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عنوان ژورنال:
- Vaccine
دوره 13 8 شماره
صفحات -
تاریخ انتشار 1995